DHODH-IN-26

• UNSPSC Description:

  DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis[1].

• Target Antigen:

  Dihydroorotate Dehydrogenase; Ferroptosis; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dhodh-in-26.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C=C3)C4=CC=C(C=C4F)NC(CC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O)C(O)=O.[Br-]

• Molecular Weight:

  787.63

• References & Citations:

  [1]Hai Y, et al. A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression. Pharmacol Res. 2024;202:107115.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported