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DHODH-IN-33

CAT: 0804-HY-179531Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179531Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHODH-IN-33 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with potent activity against A549 (IC50 = 5.22 μM) and 5637 (IC50 = 3.03 μM) . DHODH-IN-33 induces autophagy-dependent ferroptosis (mitochondrial dysfunction, lipid peroxidation, and ROS accumulation) with no notable toxicity in vivo. DHODH-IN-33 exerts anti-cancer effect by promoting the autophagy-dependent degradation of DHODH. DHODH-IN-33 can be used for non-small cell lung cancer and bladder cancer[1].
CAS Number
3026839-88-0
UNSPSC
12352005
Target
Autophagy; Ferroptosis; ROS Kinase
Related Pathways
Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC2=C(N(C3C4=CC=CC=C4OC3C2)S(=O)(C5=CC=C(C=C5)C)=O)C=C1
Molecular Formula
C23H21NO4S
Molecular Weight
407.48
References & Citations
[1]Liu CY, et al. Tetrahydrobenzofuro[3,2-b]quinoline: A dual-acting autophagy-dependent DHODH inhibitor that provokes ferroptosis in lung cancer cells. Bioorg Chem. 2025 Dec;167:109203.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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