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PHD2/HDACs-IN-1

CAT: 0931-T62298-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62298-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2339867-53-5
Target
Others, HIF/HIF Prolyl-Hydroxylase, HDAC
Related Pathways
Metabolism, Others, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
PHD2/HDACs-IN-1 is a potent mixed inhibitor of PHD2/HDACs, acting on PHD2 (IC50: 1.15 μM), HDAC1 (IC50: 19.75 μM), HDAC2 (IC50: 26.60 μM), and HDAC16 (IC50: 15.98 μM) . HDACs-IN-1 is a low toxicity nephroprotective agent suitable for studies of cisplatin-induced acute kidney injury (AKI) .
Smiles
O=C1NC(=NC=C1C(NC2CCN(CC2)C=3N=CC(C(NO)=O)=CN3)=O)N4C=CC=N4
Molecular Formula
C18H19N9O4
Molecular Weight
425.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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