AAK1/HDACs-IN-1

AAK1/HDACs-IN-1

• UNSPSC Description: AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC, that inhibits AAK1, HDAC1, and HDAC6 with IC50s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection, suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction[1].
• Target Antigen: AAK1; HDAC; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Epigenetics;Neuronal Signaling
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/aak1-hdacs-in-1.html
• Smiles: ONC(C1=CC=C(C=C1)C2=CN=C3NC=C(C3=C2)C#CC4=CN=CC=C4)=O
• Molecular Weight: 354.36
• References & Citations: [1]Mao ND, et al., Design, synthesis, and biological evaluation of novel AAK1/HDACs dual inhibitors against SARS-CoV-2 entry. Bioorg Chem. 2024 Dec;153:107973.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported