AChE/BChE-IN-6

• Description :

  AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 μM, 2.248 μM and > 100 μM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB) . AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research[1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE) ; Monoamine Oxidase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ache-bche-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C1=CC=C(C=C1)NC(OCC2CCN(CC2)CC3=CC=CC=C3)=O)C

• Molecular Formula :

  C23H30N2O2

• Molecular Weight :

  366.50

• References & Citations :

  [1]Košak U, et, al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE; BChE; MAO-B

• CAS Number :

  [2416910-94-4]