AChE/BChE-IN-6

• Description:

  AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 μM, 2.248 μM and > 100 μM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB) . AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE) ; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-bche-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC (C1=CC=C (C=C1) NC (OCC2CCN (CC2) CC3=CC=CC=C3) =O) C

• Molecular Formula:

  C23H30N2O2

• Molecular Weight:

  366.50

• References & Citations:

  [1]Košak U, et, al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; BChE; MAO-B

• CAS Number:

  2416910-94-4