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AAK1-IN-3 (TFA)

CAT: 0804-HY-144302ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144302ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AAK1-IN-3 TFA, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].
CAS Number
2761587-27-1
UNSPSC
12352005
Target
AAK1
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aak1-in-3-tfa.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC([C@H](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C24H22F6N4O4
Molecular Weight
544.45
References & Citations
[1]Richard A Hartz, et al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65 (5) :4121-4155.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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