AAK1-IN-2

• UNSPSC Description:

  AAK1-IN-2 (compound (S)-31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC50 of 5.8 nM. AAK1-IN-2 can be used for the research of neuropathic pain[1].

• Target Antigen:

  AAK1

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aak1-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CC([C@@H](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12

• Molecular Weight:

  316.40

• References & Citations:

  [1]Hartz RA, et, al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1802703-21-4