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AAK1-IN-2

CAT: 0804-HY-144301Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144301Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AAK1-IN-2 (compound (S) -31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC50 of 5.8 nM. AAK1-IN-2 can be used for the research of neuropathic pain[1].
CAS Number
1802703-21-4
UNSPSC
12352005
Target
AAK1
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aak1-in-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC([C@@H](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12
Molecular Formula
C20H20N4
Molecular Weight
316.40
References & Citations
[1]Hartz RA, et, al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65 (5) :4121-4155.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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