AAK1-IN-2 (TFA)

AAK1-IN-2 (TFA)

• CAS Number: 2761587-28-2
• UNSPSC Description: AAK1-IN-2 TFA (compound (S)-31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC50 of 5.8 nM. AAK1-IN-2 TFA can be used for the research of neuropathic pain[1].
• Target Antigen: AAK1
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aak1-in-2-tfa.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=CC([C@@H](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
• Molecular Weight: 544.45
• References & Citations: [1]Hartz RA, et, al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported