AAK1-IN-4

CAT: 0804-HY-145838Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-145838Size:1 Each
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Description
AAK1-IN-4 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50 of 4.6 nM, Filt Ki of 0.9 nM, and cell IC50 of 8.6 nM) . AAK1-IN-4 has the potential for the research for neuropathic pain[1].
CAS Number
[1815612-79-3]
UNSPSC
12352005
Target
AAK1
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aak1-in-4.html
Solubility
10 mM in DMSO
Smiles
CC(C[C@](N)(COC1=CC=C(C2=CC=NC(NC(OC)=O)=C2)N=C1C)C)C
Molecular Formula
C20H28N4O3
Molecular Weight
372.46
References & Citations
[1]Luo G, et al. Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain. J Med Chem. 2022;65 (6) :4534-4564.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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