AAK1-IN-4

AAK1-IN-4

• CAS Number: 1815612-79-3
• UNSPSC Description: AAK1-IN-4 is a highly selective, CNS-penetrable, and orally active adaptor protein-2-associated kinase 1 (AAK1) inhibitor (AAK1 IC50?of 4.6 nM, Filt?Ki?of 0.9 nM, and cell IC50 of 8.6 nM). AAK1-IN-4 has the potential for the research for neuropathic pain[1].
• Target Antigen: AAK1
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/aak1-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C[C@](N)(COC1=CC=C(C2=CC=NC(NC(OC)=O)=C2)N=C1C)C)C
• Molecular Weight: 372.46
• References & Citations: [1]Luo G, et al. Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain. J Med Chem. 2022;65(6):4534-4564.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported