Tubulin polymerization-IN-5

Tubulin polymerization-IN-5

• UNSPSC Description: Tubulin polymerization-IN-5 (compound 20q) is a potent tubulin inhibitor with potential anticancer activities. Tubulin polymerization-IN-5 can arrest ESCC cells at G2/M phase and cause cells apoptosis[1].
• Target Antigen: Apoptosis; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC(N(C(CSC(N2CCN(CC2)C(OC(C)(C)C)=O)=S)=O)CC3=CC(O)=C(C=C3)OC)=CC(OC)=C1OC
• Molecular Weight: 621.77
• References & Citations: [1]Sun YX, et al. Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities. Eur J Med Chem. 2022;229:114069.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported