Tubulin polymerization-IN-68

Tubulin polymerization-IN-68

• CAS Number: 2924156-96-5
• UNSPSC Description: Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].
• Target Antigen: Apoptosis; Caspase; Microtubule/Tubulin; PARP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-68.html
• Smiles: O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
• Molecular Weight: 263.29
• References & Citations: [1]Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported