Tubulin polymerization-IN-68
CAT:
804-HY-163983
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Tubulin polymerization-IN-68
- CAS Number: 2924156-96-5
- UNSPSC Description: Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].
- Target Antigen: Apoptosis; Caspase; Microtubule/Tubulin; PARP
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-68.html
- Smiles: O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
- Molecular Weight: 263.29
- References & Citations: [1]Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported