Tubulin polymerization-IN-45
CAT:
804-HY-155139
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tubulin polymerization-IN-45
- UNSPSC Description: Tubulin polymerization-IN-45, a tubulin-targeting agent, is a tubulin polymerization inhibitor. Tubulin polymerization-IN-45 binds to the colchicine site of tubulin. Tubulin polymerization-IN-45 induces apoptotic cell death in hepatocellular cancer (HCC) cells[1].
- Target Antigen: Apoptosis; Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-45.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(NC1=CC(OC)=CC=C1OC)C2=NNC(C3=CNC4=CC=CC=C43)=C2
- Molecular Weight: 362.38
- References & Citations: [1]Mohammed Hawash, et al. Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies. J Mol Struct. 2023 Aug 5;1285:135477.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported