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ATR-IN-10

CAT: 0804-HY-144214Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144214Size:1 Each
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Description
ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC50 value of 2.978 μM.
CAS Number
2713577-93-4
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-10.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1N(C2=C3C=C(C4=CC=CC=C4)C=CC3=NC(C5=CC=CC6=C5C=CN6)=N2)CCOC1
Molecular Formula
C27H24N4O
Molecular Weight
420.51
References & Citations
[1]Bin H, et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATR

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