PROTAC TTK degrader-2

• UNSPSC Description:

  PROTAC TTK degrader-2 is a potent TTK (threonine tyrosine kinase) PROTAC degrader, with DC50 values of 3.1 and 12.4 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-2 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-ttk-degrader-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2=NC(NC3=C(C=C(C=C3)N4CCN(CC4)C(CCCCCC#CC5=CC6=C(C=C5)CN(C7C(NC(CC7)=O)=O)C6=O)=O)OC)=NC=C2C(C)=C1)[C@@H]8CC[C@@H](CC8)NC(CC)=O

• Molecular Weight:

  884.03

• References & Citations:

  [1]Lu J, Huang Y, Huang J, et al. Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders. J Med Chem. 2022;65(3):2313-2328.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2953426-48-5