TYK2 activator-1

• Description :

  TYK2 activator-1 (16b) is a TYK2 activator with anEC50 of 1.78 μM. TYK2 activator-1 inhibits JAK2 and JAK3 with the IC50 values of 6.8 and 6.3 μM, respectively[1].

• CAS Number :

  [3087219-47-1]

• UNSPSC :

  12352005

• Target :

  JAK

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  COC1=C(C#C)C=CC=C1NC2=CC(NC3=CC(C)=C(F)C=N3)=NC=C2C(NC)=O

• Molecular Formula :

  C22H20FN5O2

• Molecular Weight :

  405.42

• References & Citations :

  [1]Matsumoto H, et al. Identification of small molecule activators targeting TYK2 pseudokinase domain. Bioorg Med Chem Lett. 2025 Aug 1;123:130233.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported