TYK2 activator-1

• Description:

  TYK2 activator-1 (16b) is a TYK2 activator with anEC50 of 1.78 μM. TYK2 activator-1 inhibits JAK2 and JAK3 with the IC50 values of 6.8 and 6.3 μM, respectively[1].

• UNSPSC:

  12352005

• Target:

  JAK

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  COC1=C(C#C)C=CC=C1NC2=CC(NC3=CC(C)=C(F)C=N3)=NC=C2C(NC)=O

• Molecular Formula:

  C22H20FN5O2

• Molecular Weight:

  405.42

• References & Citations:

  [1]Matsumoto H, et al. Identification of small molecule activators targeting TYK2 pseudokinase domain. Bioorg Med Chem Lett. 2025 Aug 1;123:130233.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3087219-47-1]