Bcl-2/Mcl-1-IN-4

Bcl-2/Mcl-1-IN-4

• UNSPSC Description: Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting Bcl-2 (Ki=0.49 μM) and Mcl-1 (Ki=0.51 μM). Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research[1].
• Target Antigen: Apoptosis; Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bcl-2-mcl-1-in-4.html
• Smiles: O=C(NS(=O)(C1=CC=C([N+]([O-])=O)C=C1)=O)[C@@H](NC(CN2C(/C(SC2=O)=C/C3=CC=C(C4=CC=C(C)C=C4)C=C3)=O)=O)CC5=CC=C(Br)C=C5
• Molecular Weight: 763.63
• References & Citations: [1]Jiabing Long, et al. "Discovery and development of thiazolidine-2, 4-dione derivatives as Bcl-2/Mcl-1 dual inhibitors." Bioorganic Chemistry (2024): 107687.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported