HPK1-IN-28

• UNSPSC Description:

  HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body's anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1)[1].

• Target Antigen:

  MAP4K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hpk1-in-28.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(OC2=NC=NC3=C2C(C4=C(F)C=C(OC)C=C4)=CN3)C(F)=CC(NC5=NCC(CO)(CO5)C)=C1

• Molecular Weight:

  513.47

• References & Citations:

  [1]Jiang Lei, et al. Novel hpk1 inhibitors and methods of preparation and application thereof. Patent WO2021175270A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2699603-89-7