Products for Research Use Only
RegisterLogin

HPK1-IN-24

CAT: 0804-HY-144091Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-144091Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HPK1-IN-24 (example 51) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with a Ki of 100 nM. HPK1-IN-24 has the potential for cancer research[1].
CAS Number
2294966-07-5
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-24.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC2=C(C=C1C3=C(C=CC=C3C)F)C(C4=CN(C)N=C4)=NN2
Molecular Formula
C19H14FN5
Molecular Weight
331.35
References & Citations
[1]Oleg VECHORKIN, et al. 6-cyano-indazole compounds as hematopoietic progenitor kinase 1 (hpk1) modulators。 WO2019051199A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1

Chemical Information

Hpk1-IN-24
CAS Number2294966-07-5
PubChem CID137545039
IUPAC Name5-(2-fluoro-6-methylphenyl)-3-(1-methylpyrazol-4-yl)-1H-indazole-6-carbonitrile
Molecular FormulaC19H14FN5
Molecular Weight331.3
XLogP3.3
Topological Polar Surface Area70.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity533
SMILES
CC1=C(C(=CC=C1)F)C2=CC3=C(C=C2C#N)NN=C3C4=CN(N=C4)C
InChI
InChI=1S/C19H14FN5/c1-11-4-3-5-16(20)18(11)14-7-15-17(6-12(14)8-21)23-24-19(15)13-9-22-25(2)10-13/h3-7,9-10H,1-2H3,(H,23,24)
InChIKey
KSWBAYVYDDFVFK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hpk1-IN-24
CAS: 2294966-07-5
CID: 137545039
Formula: C19H14FN5
MW: 331.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.3
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass331.12332363
Monoisotopic Mass331.12332363
Topological Polar Surface Area70.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-172594HPK1-IN-57
HY-170365HPK1-IN-55
HY-159905HPK1-IN-54
HY-163495HPK1-IN-44
HY-148847-01HPK1-IN-32
HY-168119HPK1-IN-53
HY-161917HPK1-IN-49
HY-161335HPK1-IN-43
HY-153362-01HPK1-IN-34
HY-138568-01HPK1-IN-3

Alternative Products

CatalogName
T60973-01HPK1-IN-24
HA722812MAP4K1 / HPK1 Recombinant Rabbit Monoclonal Antibody [PSH07-24]
YP-W22891-01Mouse HPK1 (HPK1) ELISA Kit
T211044-01HPK1-IN-59
T209691-01HPK1-IN-45
T207159-01HPK1-IN-58
T206873-01HPK1-IN-57
T200320-01HPK1-IN-47
T200066-01HPK1-IN-51
343825-01HPK1 discontinued

Popular Products