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HPK1-IN-57

CAT: 0931-T206873-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206873-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Interleukin, MAPK
Related Pathways
MAPK, Immunology/Inflammation
Bioactivity
HPK1-IN-57 (Compound 10c) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of 0.09 nM. It suppresses the activity of HPK1 kinase, inhibits the phosphorylation of downstream adaptor protein SLP76 (IC50 of 33.74 nM), and effectively induces the secretion of the T cell activation marker IL-2 (EC50 of 84.24 nM) . HPK1-IN-57 holds promise for research in tumor immunotherapy.
Smiles
CN(CC1)CCN1C2=CC=C(NC3=NC(NC4=CC=C(C(NC5CCC(F)(F)CC5)=O)C=C4)=NC=C3C(N)=O)C(OC)=C2
Molecular Formula
C30H36F2N8O3
Molecular Weight
594.655
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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