Products for Research Use Only
RegisterLogin

HPK1-IN-3

CAT: 0804-HY-138568-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-138568-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs) [1].
CAS Number
2739844-34-7
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpk1-in-3.html
Purity
98.61
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
COC1=C(NC2=NC=C(C(N)=O)C(NC3=C(F)C=CC=C3C(F)(F)F)=N2)C=C4CN(C)CCC4=C1
Molecular Formula
C23H22F4N6O2
Molecular Weight
490.45
References & Citations
[1]Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12 (4) :653-661.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1

Related Products

CatalogName
HY-172594HPK1-IN-57
HY-170365HPK1-IN-55
HY-159905HPK1-IN-54
HY-144091HPK1-IN-24
HY-163495HPK1-IN-44
HY-148847-01HPK1-IN-32
HY-168119HPK1-IN-53
HY-161917HPK1-IN-49
HY-161335HPK1-IN-43
HY-153362-01HPK1-IN-34

Alternative Products

CatalogName
BA6481-5.1HPK1-IN-3
T211106-01HPK1 ligand 3
YP-W22891-01Mouse HPK1 (HPK1) ELISA Kit
BA6488-10HPK1-IN-4
BA6484-10HPK1-IN-7
BA6487-10HPK1-IN-26
T211044-01HPK1-IN-59
T209691-01HPK1-IN-45
T207159-01HPK1-IN-58
T206873-01HPK1-IN-57

Popular Products