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HPK1-IN-57

CAT: 0804-HY-172594Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172594Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HPK1-IN-57 (Compound 10c) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.09 nM. HPK1-IN-57 inhibits the activity of HPK1 kinase, hindering the phosphorylation of the downstream adaptor protein SLP76 (IC50 is 33.74 nM) and effectively stimulating the secretion of the T cell activation marker IL-2 (EC50 is 84.24 nM) . HPK1-IN-57 is promising for research of tumor immunotherapy[1].
UNSPSC
12352005
Target
Interleukin Related; MAP4K
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(N)C1=CN=C(NC2=CC=C(C(NC3CCC(F)(F)CC3)=O)C=C2)N=C1NC4=C(OC)C=C(N5CCN(C)CC5)C=C4
Molecular Formula
C30H36F2N8O3
Molecular Weight
594.66
References & Citations
[1]Li C, et al. Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine inhibitors of hematopoietic progenitor kinase 1. Bioorg Med Chem Lett. 2025 Aug 1;123:130242.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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