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HPK1-IN-61

CAT: 0804-HY-177272Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177272Size:1 Each
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Description
HPK1-IN-61 (Compound 1) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 0.4 nM) and an inhibitor of Abl (IC50 LCK with an IC50 of 24 nM[1].
CAS Number
875638-86-1
UNSPSC
12352005
Target
Bcr-Abl; MAP4K; Src
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Smiles
NC1=C(C=C(C2=CN=C3NC=C(C3=C2)C4=C(OC)C=CC=C4)C=C1)C(N(C)C)=O
Molecular Formula
C23H22N4O2
Molecular Weight
386.45
References & Citations
[1]Chan, B. K., et al., (2021) . Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) . ACS medicinal chemistry letters, 13 (1), 84–91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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