Trk-IN-7

Trk-IN-7

• CAS Number: 2383011-61-6
• UNSPSC Description: Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50IC50=5-50 nM)[1].
• Target Antigen: Trk Receptor
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trk-in-7.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1
• Molecular Weight: 368.36
• References & Citations: [1]Diaryl macrocyclic compound as protein kinase modulator. WO2019210835A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported