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Trk-IN-7

CAT: 0804-HY-143557Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-143557Size: 1 Each
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50IC50=5-50 nM) [1].
CAS Number
[2383011-61-6]
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-7.html
Solubility
10 mM in DMSO
Smiles
FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1
Molecular Formula
C18H17FN6O2
Molecular Weight
368.36
References & Citations
[1]Diaryl macrocyclic compound as protein kinase modulator. WO2019210835A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC

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