Trk-IN-7

• UNSPSC Description:

  Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50IC50=5-50 nM)[1].

• Target Antigen:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trk-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1

• Molecular Weight:

  368.36

• References & Citations:

  [1]Diaryl macrocyclic compound as protein kinase modulator. WO2019210835A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2383011-61-6