HER2-IN-9

• Description :

  HER2-IN-9 is an orally active HER2 inhibitor, with an IC50 value of 0.03 μM. HER2-IN-9 inhibits HER-2 positive breast cancer cells proliferation and migration. HER2-IN-9 can be used in the research of breast cancers[1].

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/her2-in-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(F)(C1=CC=C(C=C1)/C=C/C2=COC(CNC3=CC=C(C=C3)Br)=N2)F

• Molecular Formula :

  C19H14BrF3N2O

• Molecular Weight :

  423.23

• References & Citations :

  [1]Xin-Yang Li, et al. Synthesis and evaluation of novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway. Eur J Med Chem. 2022 Jul 5;237:114325.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ErbB2/HER2