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HER2-IN-9

CAT: 0804-HY-143323Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143323Size:1 Each
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Description
HER2-IN-9 is an orally active HER2 inhibitor, with an IC50 value of 0.03 μM. HER2-IN-9 inhibits HER-2 positive breast cancer cells proliferation and migration. HER2-IN-9 can be used in the research of breast cancers[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/her2-in-9.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=CC=C(C=C1)/C=C/C2=COC(CNC3=CC=C(C=C3)Br)=N2)F
Molecular Formula
C19H14BrF3N2O
Molecular Weight
423.23
References & Citations
[1]Xin-Yang Li, et al. Synthesis and evaluation of novel HER-2 inhibitors to exert anti-breast cancer ability through epithelial-mesenchymal transition (EMT) pathway. Eur J Med Chem. 2022 Jul 5;237:114325.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB2/HER2

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