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HER4/HER2-IN-1

CAT: 0804-HY-178119Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178119Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HER4/HER2-IN-1 (Compound 4b) is a HER4/HER2 inhibitor. HER4/HER2-IN-1 inhibits the proliferation of HER2-positive cells. HER4/HER2-IN-1 reduces the total expression level of HER2 in A431 cells, while the phosphorylated HER2 (p-HER2) does not decrease. HER4/HER2-IN-1 lowers the level of cell cycle protein D1 (cyclin D1) and stimulates the cleavage of PARP. HER4/HER2-IN-1 can be used for the study of cancer, such as breast cancer[1].
UNSPSC
12352005
Target
CDK; EGFR; PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C(C2=CC=C(OC)C=C2)=COC3=C1C(CC(C4=C(C)C=C(C)C=C4C)C3)=O
Molecular Formula
C25H24O4
Molecular Weight
388.46
References & Citations
[1]Rubinov DB, et al. A facile method for the preparation of 7,8-dihydro-4H-chromene-4,5 (6H) -diones as non-aromatic cycle A analogs of isoflavones and their evaluation as antiproliferative agents. Bioorg Chem. 2025 Oct;165:108960.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB2/HER2; ErbB4/HER4

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