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HER2-IN-20

CAT: 0804-HY-163657Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163657Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HER2-IN-20 (compound 32) is a potent and selective HER2WT and HER2YVMA inhibitor with IC50 values of 49, 42 nM, respectively. HER2-IN-20 has the potential for the research of non-small cell lung cancer (NSCLC) [1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/her2-in-20.html
Smiles
C=CC(N1[C@@]2([H])C[C@H](N3N=C(C4=CC(F)=C(OC5=CC=C6N(C)C=NC6=C5)C(Cl)=C4)C7=C(C)N=CN=C73)C[C@]1([H])CC2)=O
Molecular Formula
C30H27ClFN7O2
Molecular Weight
572.03
References & Citations
[1]Hicken EJ, et al. Discovery of Potent and Selective Covalent Inhibitors of HER2WT and HER2YVMA. J Med Chem. 2024 May 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2

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