HER2-IN-13

CAT: 0804-HY-153557Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-153557Size:1 Each
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Description
HER2-IN-13 (Compound 33) is an HER2 inhibitor with an IC50 of 8 nM. HER2-IN-13 also inhibits wt-EGFR with an IC50 of 0.40 μM[1].
CAS Number
[2414056-34-9]
UNSPSC
12352005
Target
EGFR; Potassium Channel
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Membrane Transporter/Ion Channel; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/her2-in-13.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C1NC2=NC=NC3=C2C(O[C@H]4C(F)(CN(CC4)C)F)=C(OC)C=C3)=C(C=C1)OC5=CC6=NC=NN6C=N5
Molecular Formula
C26H23ClF2N8O3
Molecular Weight
568.96
References & Citations
[1]Ding Zhou, et al. Quinazoline derivatives as antitumor agents. Patent WO2020057511A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2

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