HER2-IN-21

• Description :

  HER2-IN-21 (compound 657994) is a human epidermal growth factor receptor 2 (HER2) inhibitor, with an IC50 of 3.85 μM[1].

• UNSPSC :

  12352005

• Target :

  EGFR

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  COC1=CC=CC(C2SC(N)=NC3=C2C(C)=NN3C(C4=CC=CC=C4O)=O)=C1

• Molecular Formula :

  C20H18N4O3S

• Molecular Weight :

  394.45

• References & Citations :

  [1]Matrouk AY, et al. Discovery of New HER2 Inhibitors via Computational Docking, Pharmacophore Modeling, and Machine Learning. Mol Inform. 2025 Feb;44 (2) :e202400336.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [906437-59-0]