HER2-IN-21

• Description:

  HER2-IN-21 (compound 657994) is a human epidermal growth factor receptor 2 (HER2) inhibitor, with an IC50 of 3.85 μM[1].

• UNSPSC:

  12352005

• Target:

  EGFR

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  COC1=CC=CC (C2SC (N) =NC3=C2C (C) =NN3C (C4=CC=CC=C4O) =O) =C1

• Molecular Formula:

  C20H18N4O3S

• Molecular Weight:

  394.45

• References & Citations:

  [1]Matrouk AY, et al. Discovery of New HER2 Inhibitors via Computational Docking, Pharmacophore Modeling, and Machine Learning. Mol Inform. 2025 Feb;44 (2) :e202400336.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  906437-59-0