PD-1/PD-L1-IN-44

• UNSPSC Description:

  PD-1/PD-L1-IN-44 (Compound 22) selectively inhibits PD-1/PD-L1 proteins (IC50=1.21 nM). PD-1/PD-L1-IN-44 inhibits tumor growth without toxicity in animal models and increases CD8+ cell infiltration[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-in-44.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C(OC2=CC=C(CN3C[C@@H](O)C[C@@H]3C(O)=O)C(OCC4=CC(C#N)=CC=C4)=C2)=O)C=CC=C1C5=CC=CC=C5

• Molecular Weight:

  562.61

• References & Citations:

  [1]Zhang Y, et al. Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1. Eur J Med Chem. 2024 May 5;271:116433.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3043669-06-0