PD-1/PD-L1-IN-44

PD-1/PD-L1-IN-44

• CAS Number: 3043669-06-0
• UNSPSC Description: PD-1/PD-L1-IN-44 (Compound 22) selectively inhibits PD-1/PD-L1 proteins (IC50=1.21 nM). PD-1/PD-L1-IN-44 inhibits tumor growth without toxicity in animal models and increases CD8+ cell infiltration[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-44.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C(OC2=CC=C(CN3C[C@@H](O)C[C@@H]3C(O)=O)C(OCC4=CC(C#N)=CC=C4)=C2)=O)C=CC=C1C5=CC=CC=C5
• Molecular Weight: 562.61
• References & Citations: [1]Zhang Y, et al. Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1. Eur J Med Chem. 2024 May 5;271:116433.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported