RORγt/DHODH-IN-3
CAT:
804-HY-142847
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
RORγt/DHODH-IN-3
- CAS Number: 2764662-16-8
- UNSPSC Description: RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity[1].
- Target Antigen: Dihydroorotate Dehydrogenase; ROR
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/rorγt-dhodh-in-3.html
- Solubility: 10 mM in DMSO
- Smiles: CC1=C(C=C(C=C1NC2=NC3=C(S2)CCC[C@@H]3O)Cl)OC4CCN(CC4)C(CC(C(F)(F)F)C(F)(F)F)=O
- Molecular Weight: 585.99
- References & Citations: [1]Chen J, et, al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported