RORγt/DHODH-IN-2

• UNSPSC Description:

  RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research[1].

• Target Antigen:

  Dihydroorotate Dehydrogenase; ROR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/rorγt-dhodh-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CCN(CC2=CC=CC(NC3=NC4=CC=CC=C4S3)=C2C)CC1)C5CCCC5

• Molecular Weight:

  434.60

• References & Citations:

  [1] Ji-An Chen, et al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2641758-86-1