RORγt/DHODH-IN-2

RORγt/DHODH-IN-2

• CAS Number: 2641758-86-1
• UNSPSC Description: RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research[1].
• Target Antigen: Dihydroorotate Dehydrogenase; ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/rorγt-dhodh-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1CCN(CC2=CC=CC(NC3=NC4=CC=CC=C4S3)=C2C)CC1)C5CCCC5
• Molecular Weight: 434.60
• References & Citations: [1] Ji-An Chen, et al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported