RORγ/DHODH-IN-2

RORγ/DHODH-IN-2

• CAS Number: 3000567-45-0
• UNSPSC Description: RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC50 values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC50 values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively[1].
• Target Antigen: Dihydroorotate Dehydrogenase; ROR; SARS-CoV
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Smiles: ClC1=C(C(F)=CC=C1)C2=NOC(C3=C(N(N=C3)C([2H])(CC(C)(C)O)[2H])C(F)(F)F)=C2C4=NC=CC=N4
• Molecular Weight: 497.87
• References & Citations: [1]Herrmann A, et al. Orally Bioavailable RORγ/DHODH Dual Host-Targeting Small Molecules with Broad-Spectrum Antiviral Activity[J]. Antiviral Research, 2024: 106008.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported