RORγ/DHODH-IN-1

RORγ/DHODH-IN-1

• CAS Number: 3000567-76-7
• UNSPSC Description: RORγ/DHODH-IN-1 (compound 1404), a deuterium labeled compound, is a dual RORγ and DHODH inhibitor with IC50 values of 9.7 nM and 100 nM, repaectively. RORγ/DHODH-IN-1 blocks the replication of SARS-CoV-2, HCMV, and non-enveloped DNA virus (HAdV5)[1].
• Target Antigen: Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Isotope-Labeled Compounds; ROR
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Smiles: ClC(C=CC=C1F)=C1C2=NOC(C3=C(N(C4=CC(Cl)=CC=C4)N=C3)C(F)(F)F)=C2C([2H])([2H])OC5CC5
• Molecular Weight: 514.30
• References & Citations: [1]Alexandra Herrmann, et al. Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity. Antiviral Res. 2024 Sep 19:231:106008.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported