RORγt/DHODH-IN-1

RORγt/DHODH-IN-1

• CAS Number: 2764662-15-7
• UNSPSC Description: RORγt/DHODH-IN-1 (compound (R)-14d) is a potent and orally active dual RORγt/DHODH inhibitor, with IC50s of 0.083 μM and 0.172 μM, respectively. RORγt/DHODH-IN-1 exhibits remarkable in vivo anti-inflammatory activity[1].
• Target Antigen: Dihydroorotate Dehydrogenase; ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/rorγt-dhodh-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C=C(C=C1NC2=NC3=C(S2)CCC[C@H]3O)Cl)OC4CCN(CC4)C(CC(C(F)(F)F)C(F)(F)F)=O
• Molecular Weight: 585.99
• References & Citations: [1]Chen J, et, al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported