BMS-665053

• UNSPSC Description:

  BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM)[1].

• Target Antigen:

  CRFR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-665053.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CN([C@H](C2CC2)C)C(C(NC3=C(Cl)C=C(OC(F)F)C=C3Cl)=N1)=O

• Molecular Weight:

  424.66

• References & Citations:

  [1]Jianqing Li, et al. An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist. Organic Process Research & Development, 16, 156-159.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1173435-64-7