BMS-665053

• Description :

  BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM) . BMS-665053) 11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM) [1].

• UNSPSC :

  12352005

• Target :

  CRFR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bms-665053.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=CN([C@H](C2CC2)C)C(C(NC3=C(Cl)C=C(OC(F)F)C=C3Cl)=N1)=O

• Molecular Formula :

  C16H14Cl3F2N3O2

• Molecular Weight :

  424.66

• References & Citations :

  [1]Jianqing Li, et al. An Efficient, Direct Bis-ortho-chlorination of 4- (Difluoromethoxy) aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist. Organic Process Research & Development, 16, 156-159.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1173435-64-7]