PRMT5-IN-11

• Description :

  PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex in the (sub) micromolar range.

• CAS Number :

  [2567564-33-2]

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/prmt5-in-11.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC[C@@H]1[C@@]([C@H]2O)(CC1)O[C@](N3C4=NC=NC(N)=C4N=C3)([H])[C@@H]2O

• Molecular Formula :

  C13H17N5O4

• Molecular Weight :

  307.31

• References & Citations :

  [1]Jouffroy L, et al. Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues. Org Lett. 2021 Nov 19;23 (22) :8828-8833.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PRMT5