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CDK4/6-IN-5

CAT: 0804-HY-139449Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139449Size:1 Each
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Description
CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93) .
CAS Number
2380321-50-4
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-5.html
Solubility
10 mM in DMSO
Smiles
CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](CN(CC4)S(C)(=O)=O)O)=NC=C3Cl)=CC(F)=C2N=C1[C@H](O)C)C
Molecular Formula
C22H28ClFN6O4S
Molecular Weight
527.01
References & Citations
[1]Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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