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Fludarabine triphosphate

CAT: 0804-HY-136650Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136650Size:1 Each
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Description
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine , is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2].
CAS Number
74832-57-8
Product Name Alternative
F-ara-ATP
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; Drug Metabolite; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fludarabine-triphosphate.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)([H])N2C3=NC(F)=NC(N)=C3N=C2
Molecular Formula
C10H15FN5O13P3
Molecular Weight
525.17
References & Citations
[1]Woodahl EL, et al. A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients. Cancer Chemother Pharmacol. 2009 Feb;63 (3) :391-401.|[2]Catapano CV, et al. Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate. Cancer Res. 1991 Apr 1;51 (7) :1829-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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