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Ganciclovir triphosphate

CAT: 0804-HY-131605Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131605Size:1 Each
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Description
Ganciclovir triphosphate (GCV-TP) is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate has an IC50 of 0.01 μM against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition[1].
CAS Number
86761-38-8
Product Name Alternative
GCV-TP
UNSPSC
12352005
Target
CMV; DNA/RNA Synthesis; Endogenous Metabolite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ganciclovir-triphosphate.html
Smiles
O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO
Molecular Formula
C9H16N5O13P3
Molecular Weight
495.17
References & Citations
[1]Sawdon AJ, et al. Polymeric Nanovectors Incorporated with Ganciclovir and HSV- tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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