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FD 12-9

CAT: 0804-HY-128685Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-128685Size:1 Each
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Description
FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity[1].
CAS Number
[1451741-22-2]
Product Name Alternative
Ac12Az9
UNSPSC
12352005
Target
BCRP; P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fd-12-9.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)C1=CC=CC(COC2=C(C3=CC=C(OCCOCCOCCN4N=NC(CCCCOC5=CC=C6C(C=C(C7=CC=CC=C7)OC6=C5)=O)=C4)C=C3)OC8=CC=CC=C8C2=O)=C1
Molecular Formula
C51H47N3O11
Molecular Weight
877.93
References & Citations
[1]Hu Xuesen, et al. Developing a novel strategy to treat glioblastoma : improving brain bioavailability of sorafenib with a synthetic flavonoid dimer to inhibit drug efflux in blood brain barrier.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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