FD 12-9

• Description :

  FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity[1].

• Product Name Alternative :

  Ac12Az9

• UNSPSC :

  12352005

• Target :

  BCRP; P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fd-12-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OC)C1=CC=CC(COC2=C(C3=CC=C(OCCOCCOCCN4N=NC(CCCCOC5=CC=C6C(C=C(C7=CC=CC=C7)OC6=C5)=O)=C4)C=C3)OC8=CC=CC=C8C2=O)=C1

• Molecular Formula :

  C51H47N3O11

• Molecular Weight :

  877.93

• References & Citations :

  [1]Hu Xuesen, et al. Developing a novel strategy to treat glioblastoma : improving brain bioavailability of sorafenib with a synthetic flavonoid dimer to inhibit drug efflux in blood brain barrier.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1451741-22-2]