FD-895

• Description:

  FD-895 is a spliceosome modulator derived from a polyketide natural product, targeting the SF3b subunit of the spliceosome. FD-895 possesses core biological activities for regulating RNA splicing (intron retention, alternative splicing) and inducing apoptosis of cancer cells. FD-895 can be used for the research of cancer, such as chronic lymphocytic leukemia (CLL) [1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; DNA/RNA Synthesis

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CC[C@H](OC)[C@H]([C@]1([H])[C@]([C@H](O)[C@H](C)/C=C/C=C([C@@H](O2)[C@H](/C=C/[C@@H]([C@](O)(CC[C@@H](O)CC2=O)C)OC(C)=O)C)\C)([H])O1)C

• Molecular Formula:

  C31H50O9

• Molecular Weight:

  566.72

• References & Citations:

  [1]Dhar S, et al. A Carbohydrate-Derived Splice Modulator. J Am Chem Soc. 2016 Apr 20;138 (15) :5063-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [147025-57-8]