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ORIC-101

CAT: 1410-M13546-01Size: 1 EachDry Ice: NoHazardous: No
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Description
ORIC-101 (ORIC101) is a highly potent, selective steroidal glucocorticoid receptor (GR) antagonist (IC50=5.6 nM) with reduced androgen receptor (AR) agonistic activity.
CAS Number
2222344-98-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
501.755
Molecular Formula
C34H47NO2
Notes
Research use only, not for human use.
Receptor
GR

Chemical Information

Oric-101

Glucocorticoid Receptor Antagonist ORIC-101 is a mifepristone-based steroidal glucocorticoid receptor (GR) antagonist with potential antineoplastic activity. Upon oral administration, ORIC-101 selectively binds to GRs, thereby inhibiting the activation of GR-mediated proliferative and anti-apoptotic gene expression pathways. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is overexpressed in certain tumor types and may be associated with tumor cell proliferation and treatment resistance. Inhibition of GR activity may potentially slow tumor cell growth and disease progression in certain cancers. Due to its reduced androgen receptor (AR) agonistic activity and improved cytochrome P450 2C8 (CYP2C8) and 2C9 (CYP2C9) inhibition profile, ORIC-101 may be useful in the treatment of AR-positive tumors with reduced potential for drug-drug interactions.

CAS Number2222344-98-9
PubChem CID134415769
IUPAC Name(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Molecular FormulaC34H47NO2
Molecular Weight501.7
XLogP6.9
Topological Polar Surface Area40.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count37
Formal Charge0
Complexity982
SMILES
CC(C)N(C)C1=CC=C(C=C1)[C@H]2C[C@]3([C@@H](CC[C@]3(C#CC(C)(C)C)O)[C@H]4[C@H]2[C@H]5CCC(=O)C=C5CC4)C
InChI
InChI=1S/C34H47NO2/c1-22(2)35(7)25-11-8-23(9-12-25)29-21-33(6)30(16-17-34(33,37)19-18-32(3,4)5)28-14-10-24-20-26(36)13-15-27(24)31(28)29/h8-9,11-12,20,22,27-31,37H,10,13-17,21H2,1-7H3/t27-,28-,29+,30-,31+,33-,34+/m0/s1
InChIKey
VNLTWJIWEYPBIF-KMSLUKAPSA-N
Chemical Structure
2D Structure
2D structure of Oric-101
CAS: 2222344-98-9
CID: 134415769
Formula: C34H47NO2
MW: 501.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight501.7
XLogP36.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass501.360679742
Monoisotopic Mass501.360679742
Topological Polar Surface Area40.5 Ų
Heavy Atom Count37
Formal Charge0
Complexity982
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T16404-01ORIC-101
A19587-100ORIC-101 100mg
A19587-25ORIC-101 25mg
A19587-5ORIC-101 5mg
A19587-1ORIC-101 1mg
A19587-50ORIC-101 50mg
A19587-10ORIC-101 10mg
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