FD-IN-1

• Description:

  FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 μM, respectively[1].

• UNSPSC:

  12352005

• Target:

  Complement System

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fd-in-1.html

• Purity:

  99.24

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C (O) CC1=CC=CC=C1OCC2=CC=CC (C3=CC ([C@H] (N) CO) =CC=C3) =C2

• Molecular Formula:

  C23H23NO4

• Molecular Weight:

  377.43

• References & Citations:

  [1]Karki RG, et al. Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. J Med Chem. 2019 May 9;62 (9) :4656-4668.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1646682-14-5