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C-Kit-IN-2

CAT: 0804-HY-128602Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128602Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].
CAS Number
2121515-37-3
UNSPSC
12352005
Target
C-Kit
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-kit-in-2.html
Solubility
10 mM in DMSO
Smiles
CCN1CCN(C2=CC(NC3=NC=C(C4=CC=C(NC(NC5=NOC(CC)=C5)=O)C=C4)S3)=NC=N2)CC1
Molecular Formula
C25H29N9O2S
Molecular Weight
519.62
References & Citations
[1]Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62 (8) :3940-3957.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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