2'-C-Methyladenosine

2'-C-Methyladenosine

• CAS Number: 15397-12-3
• UNSPSC Description: 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].
• Target Antigen: HCV
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/2-c-methyladenosine.html
• Purity: 99.63
• Solubility: DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC[C@@H]1[C@@H](O)[C@@](C)(O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1
• Molecular Weight: 281.272
• References & Citations: [1]Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84.|[2]John I Robinson, et al. Concentration of 2'C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of Leishmania RNA virus 1 via its RNA polymerase. J Biol Chem. 2018 Apr 27;293(17):6460-6469.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported