Glutaminase C-IN-2

• UNSPSC Description:

  Glutaminase C-IN-2 (compound 11) is glutaminase C (GAC) allosteric inhibitor with an IC50 of 10.64 nM. Glutaminase C-IN-2 regulates the cellular metabolite, thereby increasing reactive oxygen species (ROS) by blocking glutamine metabolism. Glutaminase C-IN-2 has anticancer effects[1].

• Target Antigen:

  Glutaminase; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/glutaminase-c-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=NN=C(N[C@H]2CN(C3=NN=CC=C3)CC2)S1)CC4=CC=CC(OC5=CC=CC=C5)=C4

• Molecular Weight:

  473.55

• References & Citations:

  [1]Hanyu Sun, et al. Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. ACS Med Chem Lett. 2023 Sep 28;14(10):1455-1466.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3056437-77-2