Glutaminase C-IN-2

Glutaminase C-IN-2

• CAS Number: 3056437-77-2
• UNSPSC Description: Glutaminase C-IN-2 (compound 11) is glutaminase C (GAC) allosteric inhibitor with an IC50 of 10.64 nM. Glutaminase C-IN-2 regulates the cellular metabolite, thereby increasing reactive oxygen species (ROS) by blocking glutamine metabolism. Glutaminase C-IN-2 has anticancer effects[1].
• Target Antigen: Glutaminase; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/glutaminase-c-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=NN=C(N[C@H]2CN(C3=NN=CC=C3)CC2)S1)CC4=CC=CC(OC5=CC=CC=C5)=C4
• Molecular Weight: 473.55
• References & Citations: [1]Hanyu Sun, et al. Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. ACS Med Chem Lett. 2023 Sep 28;14(10):1455-1466.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported