12 (S) -HETE

CAT: 0804-HY-124404ASize: 100 μg (312.04 μM x 1 mL in Ethanol)Dry Ice: NoHazardous: No
CAT#:0804-HY-124404ASize:100 μg (312.04 μM x 1 mL in Ethanol)
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Description
12 (S) -HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12 (S) -HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells[1][2].
CAS Number
[54397-83-0]
UNSPSC
12352211
Hazard Statement
H225, H319
Target
DNA/RNA Synthesis; ERK; p38 MAPK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/12-s-hete.html
Concentration
312.04 μM * 1 mL in Ethanol
Purity
99.10
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.47
Precautions
H225, H319
References & Citations
[1]Ding XZ, et al. 12-lipoxygenase metabolite 12 (S) -HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int J Cancer. 2001 Dec 1;94 (5) :630-6.|[2]Tang DG, et al. 12 (S) -HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis. Biochem Biophys Res Commun. 1995 Jun 15;211 (2) :462-8.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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