12(S)-HETE

• UNSPSC Description:

  12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells[1][2].

• Target Antigen:

  DNA/RNA Synthesis; ERK; p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;MAPK/ERK Pathway;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/12-s-hete.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O

• Molecular Weight:

  320.47

• References & Citations:

  [1]Ding XZ, et al. 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int J Cancer. 2001 Dec 1;94(5):630-6.|[2]Tang DG, et al. 12(S)-HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis. Biochem Biophys Res Commun. 1995 Jun 15;211(2):462-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  54397-83-0