12 (S) -HETE

• Description :

  12 (S) -HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12 (S) -HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H225, H319

• Target :

  DNA/RNA Synthesis; ERK; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/12-s-hete.html

• Concentration :

  312.04 μM * 1 mL in Ethanol

• Purity :

  99.10

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O

• Molecular Formula :

  C20H32O3

• Molecular Weight :

  320.47

• Precautions :

  H225, H319

• References & Citations :

  [1]Ding XZ, et al. 12-lipoxygenase metabolite 12 (S) -HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int J Cancer. 2001 Dec 1;94 (5) :630-6.|[2]Tang DG, et al. 12 (S) -HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis. Biochem Biophys Res Commun. 1995 Jun 15;211 (2) :462-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, 2 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [54397-83-0]