12-HETE-d8

• Description:

  12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].

• UNSPSC:

  12352211

• Target:

  Apoptosis

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Concentration:

  304.40 μM * 250 μL in Acetonitrile

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC/C ([2H]) =C (CC ([2H]) (/C ([2H]) =C/C ([2H]) =C (C/C ([2H]) =C (CCCC (O) =O) /[2H]) /[2H]) O) /[2H]

• Molecular Formula:

  C20H24D8O3

• Molecular Weight:

  328.52

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838.|[3]Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40.|[4]Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22 (1) :257-64.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2525175-25-9