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12 (R) -HETE

CAT: 0804-HY-124404-01Size: 5 μg (312.04 μM x 50 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-124404-01Size:5 μg (312.04 μM x 50 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12 (R) -HETE is a metabolite of Arachidonic acid, AA and can be found in skin from psoriatic lesions. 12 (R) -HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium[1][2][3][4].
CAS Number
82337-46-0
UNSPSC
12352211
Target
Aryl Hydrocarbon Receptor; Na+/K+ ATPase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/12-r-hete.html
Concentration
312.04 μM * 100 μL in Ethanol
Purity
99.90
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(O)=O)O
Molecular Formula
C20H32O3
Molecular Weight
320.47
References & Citations
[1]Schwartzman ML, et al., 12 (R) -hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+, K+-ATPase in the cornea. Proc Natl Acad Sci U S A. 1987 Nov;84 (22) :8125-9. |[2]Bacon KB, et al., Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. Br J Pharmacol. 1988 Nov;95 (3) :966-74.|[3]Powell WS, et al., Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. J Leukoc Biol. 1995 Feb;57 (2) :257-63.|[4]Chiaro CR, et al., 12 (R) -Hydroxy-5 (Z),8 (Z),10 (E),14 (Z) -eicosatetraenoic acid [12 (R) -HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol. 2008 Dec;74 (6) :1649-56.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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