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8 (S) -HETE

CAT: 0804-HY-112653-01Size: 25 μg (312.04 μM x 250 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-112653-01Size:25 μg (312.04 μM x 250 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8 (S) -HETE (8 (S) -Hydroxyeicosatetraenoic acid) is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8 (S) -HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
CAS Number
98462-03-4
Product Name Alternative
8 (S) -Hydroxyeicosatetraenoic acid
UNSPSC
12352211
Hazard Statement
H225, H319
Target
PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8_S_-HETE.html
Concentration
312.04 μM * 250 μL in Ethanol
Purity
99.9
Smiles
CCCCC/C=C\C/C=C/C=C\[C@H](C/C=C\CCCC(O)=O)O
Molecular Formula
C20H32O3
Molecular Weight
320.47
Precautions
H225, H319
References & Citations
[1]Hughes, et al. Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin. Biochim. Biophys. Acta 1081 (3), 347-354 (1991) .
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported

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